Sr. Principal Scientist Oncology Translational Research, Prostate

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com

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Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Translational Discovery & Development Biomarkers

Job Category:

Scientific/Technology

All Job Posting Locations:

Cambridge, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

About Oncology

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

We are seeking a highly motivated Senior Principal Scientist/ Associate Director in the Translational Research organization to lead biomarker and translational science efforts across pre-NME through late clinical development programs in prostate cancer.

This role will drive the design, implementation, and interpretation of biomarker strategies supporting early and late-stage clinical trials, including both registrational and exploratory studies. The successful candidate will work within a highly matrixed development environment to integrate translational science with clinical development, ensuring that biomarker data informs patient selection, pharmacodynamic assessment, and mechanisms of response and resistance.

The candidate will partner closely with clinical development, biostatistics, diagnostics, regulatory, discovery research, and external academic collaborators to translate biological insights into actionable clinical strategies.

This position requires deep scientific expertise, strong organizational and project leadership skills, and the ability to communicate complex scientific findings effectively to diverse audiences and influence across a team matrix. Activities of the role include but are not limited to:

Translational Research & Biomarker Strategy

• Lead development and execution of integrated translational research internal and external scientific endeavors and biomarker strategies for prostate cancer drug development programs.
• Design biomarker plans aligned with therapeutic mechanism of action and clinical development objectives pharmacodynamic (PD), target engagement (TE), response, safety and resistance.
• Ensure biomarker strategies address key clinical questions including; Patient stratification or enrichment, Pharmacodynamic biomarkers, Target engagement, Mechanisms of response and resistance.
• Guide selection and prioritization of biomarkers across multiple platforms including: Genomics and transcriptomics, Circulating biomarkers (ctDNA, plasma proteins), Tissue-based molecular and spatial biomarkers, Immunologic and tumor microenvironment profiling, Digital pathology and computational biomarker approaches.
• Design and manage in vitro experiments to reveal novel combination strategies, response and resistance patterns with other pipeline assets.

Clinical Trial Integration

• Partner with clinical development teams to integrate biomarker hypotheses into clinical trial protocols, biomarker analysis plans, and statistical analysis frameworks.
• Design biomarker sample collection and analysis strategies for Phase I–III clinical trials.
• Ensure biomarker analyses support key decision points in development programs.
• Collaborate with clinical operations and laboratory partners to ensure effective biomarker implementation.

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