Senior Scientist, In Vivo Pharmacology, Neuroscience

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

The Neuroscience TRC is committed to the development of transformational therapeutics for patients with neurodegenerative, neuromuscular and neuropsychiatric diseases. A network of internal and external partnerships across neurodegenerative and neuropsychiatric diseases and treatment modalities (small molecules, biologics and genetic medicines) supports our ambition to become leaders in neuroscience. Internal research focuses on causal human biology, matching therapeutic modality to molecular mechanism, and translational discovery enabling a rapid path to clinical proof-of-concept.

In the role as a Senior Scientistwithin In Vivo Pharmacology, the ideal candidate:

• Serves as a subject matter lead on siRNA delivery to the CNS
• Performs and directs in vivo pharmacology studies in mice, inclusive of in-life dosing (IV, SC, IP, PO, ICV), tissue collection, and tissue processing
• Performs and analyzes pharmacodynamic (PD) and efficacy readouts, including mRNA/protein expression levels, neuropathology, transcriptomics, and physiology
• Develops new assays and mouse models as needed
• Manages in vivo studies conducted at contract research organizations (CROs)
• Serves as an in vivo pharmacology representative or biology lead on program and platform teams, and as such, contributes to program strategy
• Participates in the evaluations of external assets and technologies as needed

Basic Qualifications:

• Bachelor’s Degree

• 7+ years of academic and / or industry experience

Or

• Master’s Degree

• 5+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

• 2+ of academic and / or industry experience

Preferred Qualifications:

• PhD in Neuroscience or related field is required.
• Extensive expertise and practical experience in oligonucleotide therapeutics, particularly the delivery of siRNAs and/or ASOs across the blood-brain barrier (BBB), is required.
• Expertise and practical experience in one or more of the following areas:

• Neurodegenerative disease, such as Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease, particularly with respect to animal modeling
• Neuromuscular disease, such as amyotrophic lateral sclerosis (ALS) and muscular dystrophies, particularly with respect to animal modeling
• RNA biology and splice modulation

• Extensive mouse handling experience, including common dosing routes and tissue collection from central nervous system (CNS) and peripheral tissues required
• Proficiency in standard molecular biology, biochemical, immunohistochemical, and/or muscle physiology assays required
• Experience with rodent stereotaxic surgery
• Familiarity with in vivo bioluminescence imaging
• Familiarity with transcriptomics and/or proteomics
• Experience working with contract research organization (CROs)
• Strong organizational and communication skills
• Ability to work independently and as part of a team
• Detail-oriented with a commitment to scientific rigor and reproducibility

• Adaptability in a fast-paced, collaborative research environment

#LI-Onsite

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

Compensation Overview:

Cambridge Crossing: $137,570 - $166,706 


The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

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