Senior Scientist, Discovery- Oncology In Vivo

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmacology

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based

advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every

step of the way.

About Oncology

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

We are searching for the best talent for a Senior Scientist, in Oncology Discovery, Innovative Medicine, located in Spring House, PA

Role Overview

Join our Oncology In Vivo team and drive the characterization and development of small molecules, biologics, radioligands, antibody-drug conjugates, cell therapies, and immune modulators for cancer treatment, coordinating cross-functional teams and ensuring compliance with regulatory requirements. You will lead in vivo and ex vivo studies across multiple research programs and contribute to the advancement of innovative therapies.

Key Responsibilities

• Design, execute, and interpret independently in vivo pharmacology studies to validate and characterize oncology targets and therapeutic agents.
• Develop and optimize in vivo models, including efficacy, mechanism of action, PK/PD biomarker studies, and dose/schedule evaluations in diverse cancer models.
• Lead the development and adaptation of research methods from literature or internal innovation to improve existing models.
• Perform and oversee complex in vivo preclinical cancer studies, ensuring scientific rigor, compliance with all regulatory requirements, internal quality standards and timely delivery.
• Analyze and present data using appropriate statistical methods in formats suitable for internal stakeholders and external publications.
• Collaborate across functions and contribute to projects beyond your own area, acting as a scientific resource and thought leader.
• Manage multiple projects simultaneously, coordinating with project leaders and external partners as needed.
• Mentor and supervise junior scientists, fostering technical excellence and professional growth.
• Contribute to ex vivo analyses (flow cytometry, IHC, ELISA, RT-PCR, Luminex®) and imaging studies (bioluminescent imaging for metastatic disease models) as required.
• Stay current with oncology and tumor immunology literature to integrate emerging insights into research strategies.
• Communicate clearly and professionally, delivering impactful presentations and reports to internal teams and external audiences.
• Flexibility required for occasional weekend, evening and holiday dosing or animal monitoring. Some onboarding training may be conducted in Spring House, PA site.

Qualifications

• Bachelor’s degree (BS/ BA) in the life sciences (molecular/ cellular biology, biochemistry, pharmacology, tumor immunology) with at least 10 years of relevant pharmaceutical or biotech industry/ lab/ academic experience OR a Master’s degree (MS) with at least 7 years of relevant experience, or PhD with 1-3 years of relevant post-graduate experience.
• Ability to cell culture of cancer and immune cells.
• Experience with oncology-relevant xenografts and syngeneic mouse models is required; primary grafts, orthotopic models, humanized models, or genetically engineered tumor models are preferred.
• Experience with small molecules and/ or biologics is required

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