Senior Principal Scientist Pharmacology

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Please note that this role is available across multiple countries and may be posted under different requisition numbers to comply with local requirements. While you are welcome to apply to any or all of the postings, we recommend focusing on the specific country(s) that align with your preferred location(s):

Belgium R-087821, United States of America R-108326

Remember, whether you apply to one or all of these requisition numbers, your applications will be considered as a single submission.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmacology

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

Position Title

Senior Principal Scientist Pharmacology

3Rs Portfolio Innovation and External Engagement

Location

Beerse, Belgium or Spring House, US.

Role Summary

The Sr. Principal Scientist & SIS Scientific Lead is a senior scientific role within Scientific & In Vivo Strategies (SIS), responsible for driving the identification and enablement of 3Rs innovation opportunities into the discovery and preclinical portfolio, including new approach methodologies (NAMs).

Operating within the enterprise 3Rs framework and aligned with Discovery, Product Development & Supply (DPDS), PSTS (Preclinical Safety and Translational Sciences), and SIS strategic priorities, this role brings deep NAMs expertise (i.e., refined in vivo, ex vivo, complex in vitro models (CIVMs)/microphysiological systems (MPS)/organoids, and/or in silico approaches) to enable portfolio‑relevant 3Rs innovation that strengthens discovery and preclinical assessment and improves preclinical-to-clinical translatability while advancing 3Rs objectives. The individual will serve as a NAMs subject‑matter expert for SIS, DPDS, and Therapeutic Area stakeholders, ensuring that both internal and external NAM opportunities are identified and evaluated through portfolio‑relevant, translational, and regulatory‑aligned perspectives.

Primary Responsibilities:

NAMs Scientific Engagement and Portfolio Integration:

• Engage with fellow SIS Scientific Leads and stakeholders to identify and evaluate ex vivo, in vitro, and in silico (in partnership with data science colleagues) NAM opportunities relevant to discovery and development programs
• Provide subject-matter expert-level guidance on applicability, strengths, limitations and readiness of NAMs within specific disease, modality and contexts of use
• Drive relevant incorporation of NAMs into program strategies, ensuring alignment with portfolio goals, scientific rigor and the broader enterprise 3Rs innovation framework

External NAMs Landscape and Regulatory Awareness:

• Maintain active awareness of the external NAMs landscape, including academic advances, emerging platforms and biotech innovations
• Evaluate external NAM developments in the context of scientific maturity, translational relevance, and evolving global regulatory perspectives (e.g., FDA, EMA, ICH, etc.)
• Translate external and regulatory signals into clear, balanced scientific insights to inform on current NAMs integration opportunities as well as to anticipate future state

Internal Capability Enablement:

• Liaison with fellow SIS Scientific Leads as well as internal functional and therapeutic area teams to assess existing NAM capabilities and gaps, relative to portfolio needs and regulatory expectations
• Inform prioritization of NAM development/evaluation and validation efforts based on scientific value-add, feasibility and anticipated regulatory acceptance
• Support development of internal guidance to enable confident and consistent application of NAMs

Scientific Collaboration and Communication:

• Serve as a scientific thought partner to drive project teams to consider 3Rs innovation/NAM-enabled approaches
• Contribute to internal scientific reviews, forums and working groups focused on 3Rs/NAMs innovation
• Support external scientific publications, presentations and internal communications that strengthen credibility and understanding of NAM-based strategies

Domestic and international travel may be required; up to 10%.

May perform other duties and matrix manage team members as assigned.

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