Senior Manager, Biophysics, Higher-Order Structure & Separations

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmaceutical Product R&D

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for Senior Manager, Biophysics, Higher-Order Structure & Separations.

Purpose: We are seeking an experienced scientific leader to build and lead our Biophysics, Higher-Order Structure & Separations team within Cell Engineering and Analytical Sciences (CEAS).

This is a unique opportunity to create and advance a scientific capability that directly impacts how biologic drug candidates progress from late Discovery through Cell Line Development and into process and product development. Working at the intersection of molecular characterization, cell line development, analytical sciences, and manufacturing, this team will generate the insights needed to understand how molecular properties influence development success.

As biologic modalities become increasingly complex, successful development requires more than characterization alone. It requires a mechanistic understanding of how molecular structure, stability, heterogeneity, and intermolecular interactions influence expression, product quality, process robustness, and manufacturability.

As the leader of this organization, you will build and guide a team of scientists responsible for answering these critical questions and translating scientific understanding into improved development outcomes across a diverse biologics portfolio.

Why This Role Matters

The next generation of biologic therapeutics will require deeper understanding of how molecular properties translate into successful development and manufacturing outcomes.

This role offers a unique opportunity to build a scientific organization that bridges molecular characterization and biologics development. By combining biophysical sciences, higher-order structure characterization, separation sciences, and complementary mass spectrometry approaches, this team will help transform molecular understanding into actionable development strategies.

The successful candidate will shape a capability that not only characterizes molecules, but helps explain why they behave the way they do throughout development, informs solutions to complex technical challenges, and ultimately improves the probability of delivering successful therapies to patients.

The Opportunity

The Biophysics, Higher-Order Structure & Separations team will work in close partnership with Mass Spectrometry, Cell Line Development, Discovery, Protein Engineering, Process Development, and Analytical Sciences to provide a comprehensive understanding of therapeutic proteins from sequence through higher-order structure and molecular behavior.

Unlike traditional developability organizations focused on candidate selection, this team's mission is to support molecules that are actively advancing through development by generating the molecular insights needed to maximize the probability of technical and manufacturing success.

The successful candidate will establish a scientific capability that helps explain:

• Why certain molecules express more effectively during cell line development
• How molecular structure and stability influence product quality outcomes
• Which molecular properties drive aggregation, heterogeneity, or process challenges
• How higher-order structure and solution behavior impact manufacturability
• What risks can be identified and mitigated early to improve development success

The team's scientific contributions will directly influence cell line development strategies, process development decisions, product quality understanding, and overall manufacturing readiness.

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