Senior Associate Scientist, Neuroscience, In Vivo Pharmacology

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Position Summary

We are seeking a detail-oriented scientist to support high-throughput screening efforts within our neuroscience drug discovery organization. This role will focus on developing and executing scalable assays for compound/oligo screening campaigns, driving identification of novel therapeutic targets and modulators.

Key Responsibilities

• Develop, optimize, and validate assays for high-throughput and high-content screening applications
• Execute compound screening campaigns, including cell viability and reporter-based assays
• Design and implement genetic perturbation screens (e.g., siRNA/ASO, CRISPR-based) to support therapeutic discovery
• Perform high-content imaging and automated image analysis to extract quantitative phenotypic data
• Maintain and scale mammalian cell culture systems, including cell lines and neuroscience-relevant in vitro models, to support screening throughput
• Troubleshoot assay performance issues and implement process improvements to ensure data quality and reproducibility
• Analyze large screening datasets; visualize and present results to support go/no-go decisions
• Document protocols and results in accordance with scientific and quality standards
• Partner cross-functionally with automation, informatics, and target validation teams to advance screening pipelines

Basic Qualifications

• Bachelor's degree in Biology, Neuroscience, Pharmacology, Biochemistry, or a related field plus 4+ years of relevant experience,
• Or a Master's degree plus 2+ years of relevant experience

Preferred Qualifications

• Hands-on academic, biotechnology, or pharmaceutical experience, including mammalian cell culture
• Experience in assay development, compound screening, genetic perturbation, and troubleshooting at scale
• Proficiency in cell viability and reporter assays, high-content imaging and analysis, and general molecular/cellular assay techniques
• Experience with cell lines and other relevant in vitro systems; familiarity with primary neuronal or iPSC-derived cultures a plus
• Ability to independently design, execute, troubleshoot, document, analyze, and present reproducible experiments; strong data analysis or visualization skills desirable
• Strong organizational and communication skills; able to work independently and cross-functionally in a fast-paced environment
• Curiosity, initiative, adaptability, attention to detail, problem-solving, and commitment to scientific rigor, safety, and data quality
• Familiarity with automation/robotics platforms and large dataset handling preferred

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

Compensation Overview:

Cambridge Crossing: $105,040 - $127,287 


The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

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