Scientist, Process Analytics, Synthetic Molecule Process Development

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist, Process Analytics, Synthetic Molecule Process Development in our Cambridge office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as a Scientist, Process Analytics where you will provide support for process chemistry and engineering efforts through specialized expertise in off-line analytical method development aimed at route scouting, optimizing reactions and understanding mechanisms for synthetic molecules. You will also provide theoretical and conceptual input to the design, development, and execution of research assignments for specific projects. Additionally, you will independently plan and execute most unit operation characterization and optimization experiments within their area of expertise and develop an awareness of unit operations in other areas. This role is responsible for significant or sole technical leadership within projects or complex studies, proactively identifying process or study issues and challenges, and proposing potential resolutions. As part of the Process Analytics (PA) Group for Synthetic Molecule Process Development (SMPD, Drug Substance (DS)), you will report to Head, Process Analytics, Synthetic Molecule Process Development.

How you will contribute:

• Design and execute drug substance process development analytical activities including phase-appropriate method development, preliminary isolation/identification of process impurities, understanding reaction kinetics/mechanism, and data management.
• Collaborate with drug substance process chemistry, analytical development and engineering to design and execute experiments for process optimization, scale-up, and technology transfer activities.
• Execution of analytical testing's for small molecule pharmaceuticals, such as HPLC, LC-MS, GC, KF, NMR, and solid state characterizations (XRPD, DSC, TGA, DVS) when needed
• Identify critical in-process-control issues and develop appropriate IPC methods
• Provide analytical support and expertise to troubleshoot process-related issues and implement corrective actions.
• Method development support for innovation and technology team, including support for Process Analytical Technology (PAT) and High throughput experimentation (HTE) teams.
• Analyze and interpret analytical data to assess process performance, identify trends, and make data-driven decisions to improve process efficiency and product quality.
• Stay updated on emerging trends and advancements in analytical chemistry, and process optimization methodologies. Identify opportunities for continuous improvement in analytical techniques, processes, and systems.
• Technology advancement: work cross-functionally to ensure continued innovation for the PA team and SMPD.
• Platform consolidation of analytical data so that chemists and engineers can easily access data, accelerate processing time, and integrate results.
• Contribute to complex/multiple projects or functional areas through leading or influencing others.
• Influence and support initiatives related to driving scientific and technical improvement within function and potentially cross-functionally.
• Ensure a productive and development-rich environment.
• Define more complex/novel approaches and methodologies to solving complex technical challenges.
• Identify vendors and build relationships to gain access to technologies as needed to deliver pipeline goals.
• Understand project timelines and deliverables and plan/coordinate project work accordingly with departmental, functional, and external stakeholders.
• Provide technical leadership to project teams within area of expertise.

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