Scientist – Histology

Life at BMS

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/

Job Title: Scientist – Histology

Department: Translational

Location: San Diego – on site

FLSA Status: Exempt

Background

RayzeBio Inc. is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC). Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

Job Description

We are seeking a highly motivated, knowledgeable, and experienced Histology Scientist with a strong foundation in histological sciences and a proven track record of developing, optimizing, and executing tissue-based assays to join our Translational team. This is a laboratory-based role focused on supporting the advancement of novel radiopharmaceutical therapies from preclinical research through translational development and into clinical testing. The successful candidate will process, embed, and section formalin-fixed paraffin-embedded (FFPE) and frozen tissue specimens collected from radiopharmaceutical-treated preclinical models and human research tissues. The candidate will design, perform, troubleshoot, and interpret immunohistochemistry (IHC) and immunofluorescence (IF) studies to support target validation, biodistribution, pharmacodynamic, and mechanism-of-action investigations across multiple pipeline programs. The ideal candidate is a meticulous, hands-on histology professional with strong technical skills, sound scientific judgment, and a collaborative mindset who enjoys working within interdisciplinary drug discovery teams and working with tissues derived from radioactive treatment studies.

Job Responsibilities

• Perform tissue processing, embedding, and microtome sectioning of FFPE tissue blocks.

• Prepare, process, embed, section, and stain cell pellets as FFPE blocks, in addition to tissue specimens.

• Prepare and section frozen tissue specimens using a cryostat.

• Conduct H&E staining and other routine histochemical stains for tissue morphology assessment and quality control.

• Design, perform, troubleshoot, and interpret IHC and IF staining studies on FFPE and frozen tissue sections to support target validation, pharmacodynamic, biodistribution, and mechanism-of-action studies.

• Operate and maintain automated tissue stainers to ensure consistent, high-quality, and reproducible IHC/H&E staining.

• Optimize antibody titration, antigen retrieval, and staining protocols for new and existing assays, including appropriate positive and negative controls.

• Acquire, analyze, and interpret histology and imaging data using image analysis and digital pathology software.

• Maintain rigorous documentation of tissue processing, staining protocols, and experimental results.

• Collaborate closely and prospectively with translational, in vivo, imaging, and biology teams to support study design, tissue collection and preservation, assay requirements, sampling strategy, assay selection, controls, histology endpoints, execution, and data interpretation.

• Maintain and troubleshoot histology equipment, including microtomes, cryostats, and automated stainers, coordinating service and calibration as needed.

• Prepare and maintain inventory and traceability of samples handled within the histology facility, including frozen and FFPE tissue blocks and slides, and cell samples.

• Work with external CROs on IHC research assay development, troubleshooting, data transfer, and knowledge transfer.

• Serve as the histology subject-matter expert for cross-functional project teams, providing scientific and technical guidance on study design, assay selection, execution, data interpretation, and follow-up studies.

…