Principal Scientist, Biophysics & Laboratory Automation

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biotherapeutics R&D

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for Principal Scientist, Biophysics & Laboratory Automation.

Purpose: Johnson & Johnson Innovative Medicine is seeking an accomplished and highly motivated Principal Scientist, Biophysics & Laboratory Automation to join Cell Engineering and Analytical Sciences (CEAS).

You will bring deep expertise in protein characterization and separation sciences, together with the technical aptitude and motivation to translate scientific workflows into automated, digitally enabled solutions.

Working within the Biophysics & Separations team, you will lead biophysics automation efforts in close coordination with the existing CEAS automation and data science teams. Building on established infrastructure, you will develop proficiency in the group’s platforms and approaches and collaborate with Mass Spectrometry, Cell Line Development (CLD), and Process Development to connect scientific workflows and advance a shared vision for a self-driving lab.

As therapeutic proteins become more complex, development requires deeper molecular understanding at greater speed and scale. Through data digitalization—connecting experiments, instruments, data, and analytics, not simply automating individual assays—you will enable faster evaluation of molecules and cell lines, earlier identification of product quality and manufacturing risks, and more informed scientific decisions. Your work will help advance an automated, connected characterization environment that supports Speed to Clinic.

Why This Role Matters:

The future of biologics development will require us to generate deeper molecular understanding while simultaneously increasing speed, scale, and efficiency.

This role provides an opportunity to help build that future.

Rather than automating individual assays in isolation, you will help create an integrated characterization environment in which experiments, instruments, data, and analytics work together. These capabilities can enable faster evaluation of molecules during Cell Line Development, earlier identification of potential manufacturing challenges, and more rapid scientific decision-making.

Your work will help transform biophysical and analytical characterization from a series of largely manual workflows into an increasingly automated, connected, and intelligent laboratory capability, supporting CEAS and the broader organization in advancing innovative biologics from development toward the clinic.

You will be responsible for:

Lead the design, development, and implementation of automated workflows for biophysical and protein characterization assays. Drawing on deep BP expertise and working with the existing automation and data science teams, build connected workflows that make BP characterization faster, more reproducible, and easier for scientists to use.

• Build practical automated workflows: connect sample preparation, instruments, software, and data processing, leveraging scientific programming and agentic AI to develop solutions. Lead the design, development, and implementation of automated workflows for biophysical and protein characterization assays. Automate established platforms such as CE-SDS, cIEF, SEC-UV, and related separation and biophysical methods while expanding automation to new characterization technologies.

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