Principal Scientist - Computational Cancer Immunology

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

When you join BMS, you are joining a high-achieving team united by a common mission.

The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit. IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning—across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS. We do this in close partnership with scientific and clinical experts in the field, both inside and outside the company. We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines. In doing so, our work transforms the lives of patients, as well as our own lives and careers.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

We seek a creative and passionate computational biologist with deep expertise in single cell and spatial transcriptomics to join the Oncology team within Informatics and Predictive Sciences (IPS). In this role, you will serve as the scientific lead for single cell and spatial analysis across our discovery cancer immunology portfolio, applying cutting edge computational, machine learning, and advanced statistical methods to high-dimensional patient and pre-clinical data. Partnering closely with biologists, translational scientists, and fellow computational biologists, you will generate and evaluate novel therapeutic hypotheses — resolving the cellular composition, states, and spatial organization of the tumor microenvironment to identify and validate new targets. This is a hands-on individual contributor role in which your scientific depth and influence across matrix teams will directly impact the discovery and development of novel therapies for cancer patients.

Responsibilities

Responsibilities will include, but are not limited to, the following:

• Serve as the subject matter expert and hands-on analyst for single cell and spatial transcriptomics data supporting discovery cancer immunology programs.

• Design and execute end-to-end analyses of single cell and single nucleus RNA-seq data, including cell type and cell state annotation, differential abundance and expression, and cell-cell communication analysis.

• Analyze spatial transcriptomics data across sequencing- and imaging-based platforms, including deconvolution, cell typing, and spatial neighborhood and niche analysis.

• Integrate single cell and spatial readouts with complementary modalities — bulk RNA-seq, high throughput proteomics, multiplex flow cytometry, genomics, and clinical data — to build holistic translational data packages for target concept opportunities.

• Support cancer immunology discovery programs from target identification through candidate selection, partnering with program teams on target validation, mechanism of action, and translational hypotheses generated from pre-clinical models and patient-derived samples.

• Partner with biologists and translational teams upstream of data generation to shape experimental design, including platform and panel selection, sample and cohort composition, controls, and powering.

• Develop and maintain reproducible, well-documented, and reusable analysis workflows, contributing to shared codebases, pipelines, and analytical standards that benefit the broader IPS organization.

• Evaluate, benchmark, and where needed extend emerging computational methods in single cell and spatial biology, and advocate for their adoption where they create scientific advantage.

• Communicate findings and recommend follow-up actions in multiple settings (including 1:1, seminars, and team meetings). Participate in authorship of scientific reports, patents, and publications, and present methods and conclusions to publishable standards.

• Provide scientific mentorship and technical guidance to junior computational scientists and interns, and influence cross-functional matrix teams without formal reporting authority.

Qualifications

Basic qualifications:

• Bachelor's degree with 8+ years of academic/industry experience,
• Or Master's degree with 6+ years of experience,

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