Senior Global Brand Director panKRAS

PanKRAS represents one of the most exciting growth opportunities within AstraZeneca’s GI Oncology portfolio and is expected to play a pivotal role in our ambition to lead in Pancreatic, Colorectal, and Lung cancer. As Senior Director, Global Commercial, panKRAS, you will lead the global commercial strategy for AstraZeneca’s panKRAS asset, a clinical stage, oral, multi-target KRAS inhibitor, with the potential to transform outcomes for patients across multiple tumor settings where KRAS is considered to be a relevant clinical target.

Given the asset’s earlier stage of development, you will shape its commercial potential from the outset by providing strategic and commercial input to development priorities, evidence generation and key investment decisions. You will translate patient, customer, market and competitive insights into clear choices on target indications, patient populations, target product profile, differentiation and sequencing, while building the foundation for future launch excellence and leading commercial preparation for the panKRAS lead indication.

Job description

The Senior Director, Global Commercial, panKRAS will be part of the Global IO Commercial Franchise Team and will set and implement the global commercial strategy for this priority asset. Reflecting the asset’s earlier stage of development, the role will provide proactive commercial and strategic input to development priorities and decisions, working closely with Clinical Development, Global Medical Affairs, Regulatory Affairs, Diagnostics, Pricing and Market Access, Global Analytics & Insights, Digital, Corporate Affairs, regional and country teams, and other partners. The role will ensure that patient, customer, market and competitive insights inform indication prioritisation, target product profile, evidence-generation strategy, investment choices and the pathway to launch.

The role is accountable for creating a differentiated strategy and positioning, generating deep customer and market insights, supporting and informing development priorities and investment decisions for the clinical and evidence programme, delivering market-shaping programmes to maximise patient and business impact, and conducting commercial planning and preparations through to launch and beyond. It also represents Global Commercial perspectives in relevant cross-functional team and governance forums, ensuring development choices are grounded in future patient, customer and market needs.

Typical accountabilities | Job responsibilities

1. Global brand strategy and leadership

· Set and communicate a clear, differentiated and long-term global brand strategy for our panKRAS asset, aligned with the GI tumour strategy and broader Oncology priorities.

· Lead annual strategic and operational planning, including positioning, segmentation, customer strategy, value proposition, target market selection and lifecycle priorities.

· Generate deep customer, patient, market and competitive insights and translate them into choices that address unmet need and maximise value.

· Provide proactive commercial and strategic input to development priorities and decisions, including indication and patient-segment prioritisation, target product profile, evidence-generation needs, clinical development trade-offs and key investment choices.

· Develop future-focused revenue forecasts and business cases informed by robust insights and sound commercial judgement.

· Represent Global Commercial in relevant Global Product Team, development and investment decision forums, providing commercially rigorous input to evidence generation, clinical development strategy, stage-gate decisions and Phase III investment choices.

2. Launch excellence and market shaping

· Lead global launch strategy, launch readiness and execution for panKRAS across priority markets, with clear milestones, decision points and performance measures.

· Engage regional and country teams early, incorporate market feedback and establish mechanisms to share learning and accelerate adoption of best practice.

· Lead agency and vendor relationships, ensuring quality, pace, compliance, value and effective use of resources.

3. Business, budget and performance management

· Own and manage relevant global brand budgets, forecasts and resource allocation to target, with clear prioritization and financial discipline.

· Define a focused performance framework and use leading and lagging measures to identify gaps, risks and opportunities.

· Provide high-quality brand and business updates to senior leadership, generating clear decisions and follow-through.

· Proactively identify and manage strategic, operational, regulatory and reputational risks, ensuring activities comply with policy, legal, regulatory and industry requirements.

Education, qualifications, skills and experience

Essential:

· Relevant experience in pharmaceutical development and commercialization, with strong oncology commercial experience.

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