Associate Director, Oncology Translational Research, Hematology

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

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Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Translational Discovery & Development Biomarkers

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

About Oncology

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

The Heme Translational Research (TR) group is seeking an experienced clinical biomarker lead (Associate Director) to develop and execute key aspects of Johnson & Johnson Innovative Medicine’s translational efforts directed towards the clinical development of novel therapies across multiple areas of solid tumor focus.

The Associate Director will serve multiple roles within the Heme TR and specifically the Multiple Myeloma Disease Area Stronghold (MM DAS). As a Translational Research leader for specific programs, you will serve on Compound Development Teams (CDT) for the Oncology Translational Research group within the MM DAS. In addition, you will lead disease related internal/external projects to further scientific understanding of multiple myeloma.

You will provide scientific leadership in preclinical and clinical translational research programs within the Heme TR group and specifically multiple myeloma. You will develop and implement the clinical biomarker strategy for programs in early and late clinical development. Key goals will include determining proof of mechanism, informing and supporting dose, defining pharmacodynamic markers and biomarkers of response and resistance. You will need to develop strong collaborations with many functional groups across the Oncology Therapeutic Area (TA), including Discovery and Clinical organizations. Additionally, you will need to develop scientific collaborations external to the organization to develop novel insights from clinical samples into disease biology and segmentation.

Key responsibilities include:

• Manages the translational strategy and implementation for one or more pipeline assets.
• Planning and execution of discovery and validation of predictive, prognostic, safety, and disease biomarkers
• Develop, implement and deliver on the clinical biomarker strategy for the compound, participate in the compound development teams and lead pertinent working groups.
• Lead and guide working groups to implement clinical biomarker and translational research strategy and lead ongoing programs and projects.
• Managing a cross-functional translational research team including junior scientists, lab scientists, computational biologists, and other relevant functions as needed.
• Analyze, interpret and present emerging clinical biomarker data
• Regular reporting of biomarker data to the CDT and Oncology senior management.
• Responsibility for the biomarker sections in Clinical protocols, Investigator Brochures, Compound Development Plans generation of Clinical Study Report
• Managing the outstanding or in-house coordination of proposed analysis within clinical trials.
• Compliance and meeting projected timelines for project deliverables (e.g. protocol outlines, protocols, informed consent, strategy documents, analysis reports, etc.)

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